Renal Regenerative Potential of Extracellular Vesicles Derived from miRNA-Engineered Mesenchymal Stromal Cells.
MouseChemical/toxinSCIDMalen = Vehicle n=7; naive vesicle control n=8; electroporated-cell…Intravenous165 or 82.5 extracellular vesicle particles per mouse, expr…Three days after glycerol injection
Model: Acute kidney injury induced by intramuscular injection of 50% glycerol at 8 mL/kg, half the dose into each hind limb muscle
At the dose previously effective for naive vesicles the miRNA-enriched vesicles gave no significant improvement, and EV-miR10a and EV-miR486 were associated with a worsening of renal function and morphology. At a half dose that was ineffective for naive vesicles, EV-miR10a and EV-miR486 produced a…
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