THERAPY DOSSIER · th-d3a2220543bd

Extracellular vesicles from human bone marrow mesenchymal stromal cells engineered by electroporation with miRNA mimics (EV-miR10a, EV-miR127, EV-miR486)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31091699 ↗2019Mixed findings

Renal Regenerative Potential of Extracellular Vesicles Derived from miRNA-Engineered Mesenchymal Stromal Cells.

MouseChemical/toxinSCIDMalen = Vehicle n=7; naive vesicle control n=8; electroporated-cell…Intravenous165 or 82.5 extracellular vesicle particles per mouse, expr…Three days after glycerol injection

Model: Acute kidney injury induced by intramuscular injection of 50% glycerol at 8 mL/kg, half the dose into each hind limb muscle

At the dose previously effective for naive vesicles the miRNA-enriched vesicles gave no significant improvement, and EV-miR10a and EV-miR486 were associated with a worsening of renal function and morphology. At a half dose that was ineffective for naive vesicles, EV-miR10a and EV-miR486 produced a…

Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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