Sustained bile drainage decreases the organs injuries via inflammation-associated factors modulation in a severe acute pancreatitis rat model.
RatChemical/toxinSprague-DawleyFemalen = 72 female Sprague-Dawley rats, 18 per group, 6 per time poi…Externalised cannula inserted into the bile duct
Model: Severe acute pancreatitis induced by retrograde injection of 4% sodium taurocholate (1 mg/kg body weight) into the biliopancreatic duct via the duodenum
Bile drainage attenuated pancreatitis progression and multi-organ injury, significantly reduced pancreatic pathological scores and levels of amylase, TNF-alpha, HMGB1 and NF-kappaB-p65, and increased haem oxygenase-1, while interleukin-10 was unchanged.
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