THERAPY DOSSIER · th-e1d12fd6fbd1

Sustained external bile drainage via bile duct cannulation

Procedure · Sustained external bile drainage via bile-duct cannulation; surgical/interventional procedure.

Evidence & regulatory context

Mechanism: Sustained external bile drainage via bile-duct cannulation; surgical/interventional procedure.
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 2

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07558304 ↗NAnot yet recruiting

Suprapapillary vs Internal-External Transpapillary Biliary Drainage in Malignant Hilar Obstruction

Malignant Biliary Obstruction

Enrolment: 84 · Results not recorded

NCT05246176 ↗NAunknown

Ultrasonography-Guided Percutaneous Transhepatic Biliary Drainage in Obstructive Jaundice

Obstructive Jaundice

Enrolment: 50 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31086593 ↗2019Reported benefit

Sustained bile drainage decreases the organs injuries via inflammation-associated factors modulation in a severe acute pancreatitis rat model.

RatChemical/toxinSprague-DawleyFemalen = 72 female Sprague-Dawley rats, 18 per group, 6 per time poi…Externalised cannula inserted into the bile duct

Model: Severe acute pancreatitis induced by retrograde injection of 4% sodium taurocholate (1 mg/kg body weight) into the biliopancreatic duct via the duodenum

Bile drainage attenuated pancreatitis progression and multi-organ injury, significantly reduced pancreatic pathological scores and levels of amylase, TNF-alpha, HMGB1 and NF-kappaB-p65, and increased haem oxygenase-1, while interleukin-10 was unchanged.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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