Effects of depression on healing and inflammatory responses of acute wounds in rats.
RatWoundn = 100 rats randomly allocated to five groupsGiven either before wound creation (pre-antidepressant group) or after wound cr…
Model: Acute wounds created on the back combined with an aversive stimulus model of depression
Depression delayed acute wound healing and increased inflammatory cytokine concentrations relative to control, while antidepressant treatment given either before or after wounding increased the healing rate above control and lowered cytokine concentrations.
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