THERAPY DOSSIER · th-03ba5ec93ce0

Antidepressant, agent not named in the abstract

Drug · Drug-class entry with no agent named in the source abstract; no single ChEMBL entity can be assigned.

Evidence & regulatory context

Mechanism: Drug-class entry with no agent named in the source abstract; no single ChEMBL entity can be assigned.
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31077486 ↗2019Reported benefit

Effects of depression on healing and inflammatory responses of acute wounds in rats.

RatWoundn = 100 rats randomly allocated to five groupsGiven either before wound creation (pre-antidepressant group) or after wound cr…

Model: Acute wounds created on the back combined with an aversive stimulus model of depression

Depression delayed acute wound healing and increased inflammatory cytokine concentrations relative to control, while antidepressant treatment given either before or after wounding increased the healing rate above control and lowered cytokine concentrations.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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