Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis.
MouseIschaemia-reperfusionCardiacC57BL/6MaleStarted after myocardial infarction; the exact interval is not stated in the ab…
Model: Myocardial infarction produced by ligation of the left anterior descending coronary artery
Irisin alleviated cardiac dysfunction and ventricular dilation at four weeks after myocardial infarction, reduced infarct size and fibrosis, increased angiogenesis in the infarct border zone and reduced cardiomyocyte apoptosis without affecting cardiomyocyte proliferation. In endothelial cells iris…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.