THERAPY DOSSIER · th-e7ca523db3d9

Irisin, a recombinant myokine cleaved from fibronectin type III domain-containing protein 5

Hormone

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03514238 ↗NAcompleted

The Irisin and Metabolic Exercise Training Study

Obesity

Enrolment: 40 · Results not recorded

NCT03715088 ↗NAcompleted

Impacts of Resistance Training on Acute Secretion of Irisin in Obese Older and Young Adults

Obesity

Enrolment: 31 · Results not recorded

NCT05546294 ↗NAcompleted

The Effects of Aerobic Exercise on Sleep Quality, Fatigue, Quality of Life, Depression, Serum BDNF and Irisin Levels in Patients With Rheumatoid Arthritis

Rheumatoid Arthritis · Sleep Quality · Aerobic Exercise

Enrolment: 151 · Results not recorded

NCT07675382 ↗NAcompleted

Effects of an Eight-Week Whole-Body Electromyostimulation and Diet Program on Body Composition, Cardiometabolic Markers, and the Myokines Irisin and Betatrophin in Women With Obesity

Obesity

Enrolment: 44 · Results not recorded

NCT02903797 ↗Phase not recordedunknown

The Relation Between Serum Irisin Hormone Level and Endometrial Hyperplasia

Endometrial Hyperplasia

Enrolment: 80 · Results not recorded

NCT02258698 ↗Phase not recordedcompleted

Insulin Sensitivity, Irisin and Adipokines as Outcome Parameters in Patients Undergoing Cardiac Surgery

Insulin Resistance · Diabetes Mellitus Type 2

Enrolment: 348 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31061533 ↗2019Reported benefit

Irisin exerts a therapeutic effect against myocardial infarction via promoting angiogenesis.

MouseIschaemia-reperfusionCardiacC57BL/6MaleStarted after myocardial infarction; the exact interval is not stated in the ab…

Model: Myocardial infarction produced by ligation of the left anterior descending coronary artery

Irisin alleviated cardiac dysfunction and ventricular dilation at four weeks after myocardial infarction, reduced infarct size and fibrosis, increased angiogenesis in the infarct border zone and reduced cardiomyocyte apoptosis without affecting cardiomyocyte proliferation. In endothelial cells iris…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

Loading the evidence…