A self-healing hydrogel eye drop for the sustained delivery of decorin to prevent corneal scarring.
MixedWoundSprague-DawleyTopical ocular, as an eye drop
Model: Corneal injury and scarring; a rat model was used for gel retention and a corneal organ culture model was used to assess re-epithelialisation
The fluid gel gave enhanced decorin release compared with a conventional gel film, was retained on the ocular surface in vivo in rats, and significantly increased re-epithelialisation within four days of treatment in an organ culture model (P less than 0.05).
Extraction: extract · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.