Effect of Acetyl-L-carnitine Used for Protection of Neonatal Hypoxic-Ischemic Brain Injury on Acute Kidney Changes in Male and Female Rats.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMale and femaleSubcutaneous injection100 mg/kg, prepared in 8% sodium bicarbonate to control pHFirst dose immediately after hypoxia-ischaemia
Model: Rice-Vannucci neonatal hypoxia-ischaemia: right common carotid artery ligation followed by 75 min of 8% oxygen at 37 degrees C on postnatal day 7, with sham-operated controls
OCTN2/beta-actin was 1.03 plus or minus 0.04 in shams, fell to 0.80 plus or minus 0.04 after hypoxia-ischaemia (p less than 0.01) and was 1.11 plus or minus 0.06 with ALCAR. PDH/beta-actin was 1.16 plus or minus 0.06 in shams, 0.98 plus or minus 0.05 after injury (p less than 0.05) and 1.24 plus or…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.