Effect of Acetyl-L-carnitine in Migraine - Randomized, Double-blind Placebo Controlled Study
Migraine
Enrolment: 72 · Results not recorded
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Nutraceutical · Acetic acid ester of carnitine that facilitates movement of acetyl-CoA into mitochondrial matrices during fatty acid oxidation; crosses the blood-brain barrier and has reported neuroprotective, neuromodulatory and neurotrophic activity; shows nicotinic action at the neuromuscular junction and competitively inhibits alcohol dehydrogenase.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Migraine
Enrolment: 72 · Results not recorded
Amyotrophic Lateral Sclerosis
Enrolment: 246 · Results not recorded
Hepatic Encephalopathy
Enrolment not recorded · Results not recorded
Friedreich's Ataxia
Enrolment: 20 · Results not recorded
Glucose Intolerance
Enrolment: 24 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Rice-Vannucci neonatal hypoxia-ischaemia: right common carotid artery ligation followed by 75 min of 8% oxygen at 37 degrees C on postnatal day 7, with sham-operated controls
OCTN2/beta-actin was 1.03 plus or minus 0.04 in shams, fell to 0.80 plus or minus 0.04 after hypoxia-ischaemia (p less than 0.01) and was 1.11 plus or minus 0.06 with ALCAR. PDH/beta-actin was 1.16 plus or minus 0.06 in shams, 0.98 plus or minus 0.05 after injury (p less than 0.05) and 1.24 plus or…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Contusion spinal cord injury with the Infinite Horizon impactor under ketamine 80 mg/kg and xylazine 10 mg/kg anaesthesia; dorsal laminectomy at T10 exposing T9/T10 (n=12) or at T12 exposing L1/L2 (n=64), with contusions of 200 kdyn for T10 and 250 kdyn for L1/L2; shams received laminectomy only
Acetyl-L-carnitine preserved the mitochondrial respiratory control ratio and complex I driven respiration at 24 h and, after L1/L2 contusion, produced consistent weight-supported plantar stepping with greater grey and white matter sparing and more ChAT-positive lamina X neurons rostral to the epice…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.