Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage.
MixedHaemorrhage/shockUnspecifiedSprague-Dawley rats; C57BL/6 miceMale mice; sex not stated for ratsn = n = 20 per group for mortality, n = 4 to 12 for neurologica…Single tail vein injection for plasma; intraperitoneal injection for IGF-1500 microlitres of young or old rat plasma per rat; recombi…30 min after intracerebral haemorrhage surgery for both plasma and IGF-1
Model: Autologous blood injection into the striatum (75 microlitres in rats, 20 microlitres in mice); separate heterochronic versus isochronic parabiosis experiment in aged mice before intracerebral haemorrhage
Young plasma significantly reduced mortality and neurological deficit scores in aging rats after intracerebral haemorrhage compared with old plasma or saline, with lower perihaematomal brain water content, less oedema, necrosis and inflammatory infiltration, fewer Fluoro-Jade B positive degeneratin…
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