Association of TRAP1 with infliximab-induced mucosal healing in Crohn's disease.
MixedChemical/toxinTRAP1 transgenic mice and wild-type micen = 42 good responders with mucosal healing and 70 non-responde…
Model: Dextran sodium sulfate-induced acute colitis in TRAP1 transgenic mice, alongside a two-stage genome-wide association study in Korean patients with Crohn's disease
The intronic TRAP1 single nucleotide polymorphism rs2158962 was significantly associated with mucosal healing after infliximab (odds ratio 4.94). In dextran sodium sulfate-induced acute colitis, TRAP1 transgenic mice responded better to infliximab than wild-type mice, supporting TRAP1 as a genetic…
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