Prospective Analysis of Pharmacokinetic Infliximab Data in Pediatric CD Patients (ProRAPID)
Crohn Disease · Child, Only · Biologic; Inadequate
Enrolment: 50 · Results not recorded
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Biologic · TNF-alpha inhibitor
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Crohn Disease · Child, Only · Biologic; Inadequate
Enrolment: 50 · Results not recorded
Rheumatoid Arthritis
Enrolment: 45 · Results not recorded
Osteoarthritis of the Knee
Enrolment: 16 · Results not recorded
Ulcerative Colitis
Enrolment: 548 · Results not recorded
Rheumatoid Arthritis
Enrolment: 43 · Results not recorded
Ulcerative Colitis
Enrolment: 20 · Results not recorded
Spondylarthropathies
Enrolment: 1 · Results not recorded
Rheumatoid Arthritis
Enrolment: 82 · Results not recorded
Crohn Disease
Enrolment: 40 · Results not recorded
Ulcerative Colitis
Enrolment: 18 · Results not recorded
Spondylitis, Ankylosing · Arthritis, Rheumatoid · Psoriasis · Arthritis, Psoriatic
Enrolment: 1061 · Results not recorded
Inflammatory Bone Disease
Enrolment: 60 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Dextran sodium sulfate-induced acute colitis in TRAP1 transgenic mice, alongside a two-stage genome-wide association study in Korean patients with Crohn's disease
The intronic TRAP1 single nucleotide polymorphism rs2158962 was significantly associated with mucosal healing after infliximab (odds ratio 4.94). In dextran sodium sulfate-induced acute colitis, TRAP1 transgenic mice responded better to infliximab than wild-type mice, supporting TRAP1 as a genetic…
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Model: Acute liver injury induced by a single 2 mL/kg dose of carbon tetrachloride
Carbon tetrachloride raised aminotransferases, transforming growth factor beta 1, interleukin 1 beta and adenosine deaminase and lowered carbamoyl phosphate synthetase I and carbonic anhydrase II. Pretreatment with infliximab reversed these changes and reduced histological liver injury.
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Model: Intestinal ischaemia/reperfusion by 1 h superior mesenteric artery ligation followed by 1 h reperfusion, causing acute lung injury
Infliximab pre-treatment lowered lung malondialdehyde, raised antioxidant enzyme activity, reduced histological lung injury and inducible nitric oxide synthase, and increased surfactant protein D.
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Model: Acute spinal cord injury
Both agents lowered NF-kB, TRADD and FADD at 24 hours and raised BBB scores at 14 and 21 days, with the combination producing the greatest improvement.
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