Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome.
MouseRadiationMaleIntramuscular injectionProphylactic, 48 h to 12 h before irradiation with maximum effect at 24 h befor…
Model: Total body irradiation producing haematopoietic acute radiation syndrome; several total body irradiation doses used to derive a dose reduction factor
A single prophylactic intramuscular injection given 48 h to 12 h before irradiation improved survival after lethal total body irradiation, with the best effect at 24 h, and the benefit was oestrogen receptor dependent.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.