Genistein

BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high-dose radiation exposure in the C57L/J murine model.

Model: Whole thorax lung irradiation, single dose of 11.0 or 12.5 Gy, producing radiation pneumonitis and fibrosis

BIO 300 at 400 mg/kg orally for 4 to 6 weeks starting 24 h after whole thorax lung irradiation reduced morbidity and improved survival, correlating with reduced respiratory frequency and enhanced pause. Treated lungs showed less morphological damage and airway loss from oedema, congestion and fibro…

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Mechanism and therapeutic window of a genistein nanosuspension to protect against hematopoietic-acute radiation syndrome.

Model: Total body irradiation producing haematopoietic acute radiation syndrome; several total body irradiation doses used to derive a dose reduction factor

A single prophylactic intramuscular injection given 48 h to 12 h before irradiation improved survival after lethal total body irradiation, with the best effect at 24 h, and the benefit was oestrogen receptor dependent.

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Genistein attenuates di-(2-ethylhexyl) phthalate-induced testicular injuries via activation of Nrf2/HO-1 following prepubertal exposure.

Model: Di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury by daily gavage from postnatal day 22 to 35

Genistein co-administration partially reversed di-(2-ethylhexyl) phthalate-induced loss of testis weight, antioxidant enzyme activity and tubular vacuolation, and upregulated Nrf2 and HO-1, although values were not fully normalised to control.

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E-Cadherin-Mediated Cell Contact Controls the Epidermal Damage Response in Radiation Dermatitis.

Model: Ionising radiation-induced acute epidermal damage, radiation dermatitis, in rodent skin

Genistein and dasatinib reduced reactive oxygen species-induced degradation of beta-catenin and E-cadherin in vitro and ameliorated skin damage in rodent radiation dermatitis models.

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Genistein alleviates radiation-induced pneumonitis by depressing Ape1/Ref-1 expression to down-regulate inflammatory cytokines.

Model: Thoracic irradiation-induced pneumonitis

Genistein reduced acute inflammatory and fibrinoid exudation, suppressed the irradiation-induced rise in APE1 and NF-kappaB activity, and lowered TGF-beta1, IL-1beta, TNF-alpha and IL-6 in serum and bronchoalveolar lavage fluid (P<0.05).

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Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice

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Restoration of vasodilation and CBF autoregulation by genistein in rat pial artery after brain injury

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Genistein treatment protects mice from ionizing radiation injury

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Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation

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