Cardioprotective effect of melatonin and agomelatine on doxorubicin-induced cardiotoxicity in a rat model: an electrocardiographic, scintigraphic and biochemical study.
RatChemical/toxinWistarMalen = 49 male rats in seven groupsIntraperitonealMelatonin and agomelatine 40 mg/kg/day; doxorubicin 18 mg/kgPretreatment started 4 days before the first doxorubicin dose
Model: Doxorubicin-induced acute cardiotoxicity by intraperitoneal doxorubicin 18 mg/kg daily for three days
Pretreatment with melatonin, agomelatine or both normalised doxorubicin-induced electrocardiographic abnormalities and reduced serum creatine kinase, troponin T and 99mTc pyrophosphate uptake.
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