New Approach in Ulcer Prevention and Wound Healing Treatment using Doxycycline and Amoxicillin/LDH Nanocomposites.
MixedWoundAlbino ratsBoth sexesn = 84 rats in seven groups of six per experiment (98 rats repo…Oral gavage for the ulcer study; topical ointment for the wound studyAMOX/LDH and amoxicillin 40 mg/kg; DOX/LDH and doxycycline…Ulcer: once daily for 6 days before ethanol challenge with a final dose 1 h aft…
Model: Surgical incised wound of 10 by 10 mm on the dorsum under ketamine and xylazine anaesthesia, and gastric ulcer induced by oral absolute ethanol 98.9 per cent at 5 mL/kg after 24 h fasting
Both nanocomposites gave complete wound closure by day 18 compared with about 24 days in other groups and markedly lowered the ethanol ulcer index, outperforming the free antibiotics, with histology confirming the effect.
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