Melatonin improves functional recovery in female rats after acute spinal cord injury by modulating polarization of spinal microglial/macrophages.
RatSpinal cord injuryContusionWistarfemalen = n = 6 per group (melatonin and vehicle)intraperitoneal injection50 mg/kgimmediately after spinal cord injury
Model: Acute contusion spinal cord injury
Melatonin-treated rats showed higher BBB locomotor scores, smaller spinal cavities and less cleaved caspase 3 staining than vehicle controls, with decreased M1 and increased M2 microglial/macrophage markers and reduced TNF-alpha, IL-6 and IL-1beta in injured spinal cord.
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