Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy.
RatSpinal cord injuryContusionSprague-Dawleymalen = n = 8 per group (sham, spinal cord injury, spinal cord inju…intravenous tail vein injection200 microgram total sEV protein in 200 microL PBSimmediately after spinal cord injury
Model: T10 weight-drop contusion spinal cord injury (modified Allen method, 10 g rod 2.5 mm diameter dropped from 12.5 mm)
NSC-sEVs given intravenously immediately after contusion significantly increased BBB scores from weeks 2 to 4, improved gait coordination, reduced lesion area on Nissl staining and MRI, reduced TUNEL-positive cells and cleaved caspase-3 and Bax while increasing Bcl-2, reduced CD68-positive microgli…
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