THERAPY DOSSIER · th-244f6243f7b2

Neural stem cell-derived small extracellular vesicles (NSC-sEVs), from 13.5-day fetal mouse spinal cord neural stem cells

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07144241 ↗PHASE2not yet recruiting

Mesenchymal Stromal/Stem Cells-Derived Exosomes (MSC-Exos) Therapy for Type 2 Diabetes Mellitus Patients

Type 2 Diabetes Mellitus

Enrolment: 50 · Results not recorded

NCT03384433 ↗PHASE1/PHASE2unknown

Safety and Efficacy of Allogenic Mesenchymal Stem Cells Derived Exosome on Disability of Patients With Acute Ischemic Stroke

Cerebrovascular Disorders

Enrolment: 5 · Results not recorded

NCT05813379 ↗PHASE1/PHASE2unknown

Application of Mesenchymal Stem Cells Derived Exosomes in Skin Rejuvenation

Anti Aging

Enrolment: 20 · Results not recorded

NCT07295067 ↗PHASE1active not recruiting

Intrathecal Injection of Human Autologous Mesenchymal Stromal Cells Derived Extracellular Vesicles for Syringomyelia

Syringomyelia

Enrolment: 18 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31000697 ↗2019Reported benefit

Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy.

RatSpinal cord injuryContusionSprague-Dawleymalen = n = 8 per group (sham, spinal cord injury, spinal cord inju…intravenous tail vein injection200 microgram total sEV protein in 200 microL PBSimmediately after spinal cord injury

Model: T10 weight-drop contusion spinal cord injury (modified Allen method, 10 g rod 2.5 mm diameter dropped from 12.5 mm)

NSC-sEVs given intravenously immediately after contusion significantly increased BBB scores from weeks 2 to 4, improved gait coordination, reduced lesion area on Nissl staining and MRI, reduced TUNEL-positive cells and cleaved caspase-3 and Bax while increasing Bcl-2, reduced CD68-positive microgli…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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