The Proton Pump Inhibitor Lansoprazole Has Hepatoprotective Effects in In Vitro and In Vivo Rat Models of Acute Liver Injury.
RatEndotoxin/LPS
Model: D-galactosamine plus lipopolysaccharide (GalN/LPS) induced acute liver injury / fulminant liver failure; in vitro interleukin-1beta stimulated primary cultured rat hepatocytes
Lansoprazole increased survival by 50% in GalN/LPS-treated rats and decreased hepatic iNOS, TNF-alpha and cytokine-induced neutrophil chemoattractant-1 mRNA expression, and inhibited GalN/LPS-induced nuclear factor-kappa B activation. In vitro it inhibited interleukin-1beta induced iNOS induction a…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.