THERAPY DOSSIER · th-1d7ad190e6d8

Lansoprazole (LPZ), a proton pump inhibitor

Drug · Gastric H+/K+ ATPase (proton pump) inhibitor

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Evidence & regulatory context

Mechanism: Gastric H+/K+ ATPase (proton pump) inhibitor
Target: CHEMBL2095173
Injury models: Endotoxin/LPS
Reported indication: Not recorded
First approval: 1995
Development stage: Not recorded
ChEMBL record: CHEMBL480 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Lansoprazole; Prevacid; Takepron; Zoton; Ogast; Agopton; A-65006; AG-1749
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02633930 ↗PHASE4completed

H. Pylori Eradication With Berberine, Lansoprazole, Amoxicillin and Bismuth

Gastritis · Peptic Ulcer · Dyspepsia

Enrolment: 566 · Results not recorded

NCT01452724 ↗PHASE3completed

A Phase 3, Randomized, Double Blind... TAK-438 vs AG-1749 in Duodenal Ulcer

Duodenal Ulcer

Enrolment: 372 · Results not recorded

NCT03131895 ↗PHASE1completed

Bioavailability of Dexlansoprazole DR Capsules 30/60 mg

Healthy Volunteers

Enrolment: 116 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30989463 ↗2019Reported benefit

The Proton Pump Inhibitor Lansoprazole Has Hepatoprotective Effects in In Vitro and In Vivo Rat Models of Acute Liver Injury.

RatEndotoxin/LPS

Model: D-galactosamine plus lipopolysaccharide (GalN/LPS) induced acute liver injury / fulminant liver failure; in vitro interleukin-1beta stimulated primary cultured rat hepatocytes

Lansoprazole increased survival by 50% in GalN/LPS-treated rats and decreased hepatic iNOS, TNF-alpha and cytokine-induced neutrophil chemoattractant-1 mRNA expression, and inhibited GalN/LPS-induced nuclear factor-kappa B activation. In vitro it inhibited interleukin-1beta induced iNOS induction a…

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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