Bone Marrow Derived Mesenchymal Stromal Cells Ameliorate Ischemia/Reperfusion Injury-Induced Acute Kidney Injury in Rats via Secreting Tumor Necrosis Factor-Inducible Gene 6 Protein.
RatIschaemia-reperfusionRenalSprague-Dawleymalen = n = 6 per group across 6 groups; in vitro 3 wells per group…intravenous injection5 x 10^(exponent not recoverable from source encoding) BMSC…after the 45 min ischaemia, at reperfusion
Model: Bilateral renal ischaemia/reperfusion acute kidney injury by clamping both renal pedicles for 45 min
At day 3 after 45 min bilateral renal ischaemia, serum creatinine was 73.5 +/- 7.8 micromol/L with BMSC versus 392.5 +/- 24.8 micromol/L untreated and 314.0 +/- 19.8 micromol/L with DMEM, with markedly improved histology. Silencing TSG-6 largely abrogated this benefit (serum creatinine 265.1 +/- 21…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.