THERAPY DOSSIER · th-a323fbe9a21d

Rat bone marrow derived mesenchymal stromal cells (BMSC), passages 3-5, acting via secreted TNF-inducible gene 6 protein (TSG-6); TSG-6 knockdown by lentiviral shRNA and recombinant human TSG-6 used in vitro

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02685098 ↗Injury indicationPHASE1completed

A Clinical and Histological Analysis of Mesenchymal Stem Cells in Amputation

Ischemia · Peripheral Arterial Disease · Amputation

Enrolment: 81 · Results not recorded

NCT01446614 ↗PHASE1/PHASE2unknown

Phase I/II Trial of Autologous Bone Marrow Derived Mesenchymal Stem Cells to Patients With Parkinson's Disease

Parkinson's Disease

Enrolment: 20 · Results not recorded

NCT02150551 ↗PHASE1completed

Safety and Tolerability Of Allogeneic Mesenchymal Stromal Cells in Pediatric Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Enrolment: 1 · Results not recorded

NCT02195323 ↗PHASE1completed

Administration of Autologous Bone Marrow Mesenchymal Stem Cells (BM-MSCs) in Patients With Chronic Kidney Disease

Chronic Kidney Disease

Enrolment: 7 · Results not recorded

NCT04489732 ↗PHASE1completed

Pilot Study of Mesenchymal Stromal Cells in Patients With Xerostomia After Radiation Therapy for Head and Neck Cancer

Xerostomia Following Radiotherapy

Enrolment: 6 · Results not recorded

NCT02646007 ↗PHASE1unknown

Autologous Bone Marrow Derived Mesenchymal Stromal Cells Transplantation for Avascular Necrosis of the Lunate Bone

Kienbock's Disease

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30984789 ↗2019Reported benefit

Bone Marrow Derived Mesenchymal Stromal Cells Ameliorate Ischemia/Reperfusion Injury-Induced Acute Kidney Injury in Rats via Secreting Tumor Necrosis Factor-Inducible Gene 6 Protein.

RatIschaemia-reperfusionRenalSprague-Dawleymalen = n = 6 per group across 6 groups; in vitro 3 wells per group…intravenous injection5 x 10^(exponent not recoverable from source encoding) BMSC…after the 45 min ischaemia, at reperfusion

Model: Bilateral renal ischaemia/reperfusion acute kidney injury by clamping both renal pedicles for 45 min

At day 3 after 45 min bilateral renal ischaemia, serum creatinine was 73.5 +/- 7.8 micromol/L with BMSC versus 392.5 +/- 24.8 micromol/L untreated and 314.0 +/- 19.8 micromol/L with DMEM, with markedly improved histology. Silencing TSG-6 largely abrogated this benefit (serum creatinine 265.1 +/- 21…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.88. Machine-extracted fields require source verification.

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