Arather than Aadenosine receptor as a possible target of Guanosine effects on mitochondrial dysfunction following Traumatic Brain Injury in rats.
RatTBIFluid percussionWistarMale7.5 mg/kgSingle dose 40 min after fluid percussion injury
Model: Fluid percussion injury (FPI)
A single dose of guanosine 40 min after fluid percussion injury protected against loss of mitochondrial membrane potential and the rise in reactive oxygen species at 8 h. Protection was abolished by DPCPX but not by SCH 58261, implicating the A1 adenosine receptor.
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