Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- TBI
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 2
2 studies reported at therapy level; 2 evidence entries itemised.
RatTBIFluid percussionWistarMale7.5 mg/kgSingle dose 40 min after fluid percussion injury
Model: Fluid percussion injury (FPI)
A single dose of guanosine 40 min after fluid percussion injury protected against loss of mitochondrial membrane potential and the rise in reactive oxygen species at 8 h. Protection was abolished by DPCPX but not by SCH 58261, implicating the A1 adenosine receptor.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
RatTBIFluid percussionWistarMale7.5 mg/kg15 minutes after injury
Model: Unilateral moderate fluid percussion brain injury
Fluid percussion injury caused mitochondrial dysfunction and reduced glutamate uptake and glial glutamate transporter levels, and guanosine ameliorated both the mitochondrial damage and the glutamatergic dyshomeostasis.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
