Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury.
MixedSpinal cord injuryContusionSprague-Dawley rats and C57BL/6 mice (per MeSH indexing)Female (per MeSH indexing)500 nmol/kgAdministered acutely post-injury
Model: Spinal cord contusion injury in rats and mice, with parallel rat primary spinal microglia, BV2 cell and monocyte-derived macrophage cultures
Acute DHA at 500 nmol/kg conferred neuroprotection and improved locomotor recovery after contusion spinal cord injury, and reduced myelin phagocytosis by microglia at 7 days in parallel with increased miR-124. A miR-124 inhibitor reversed the reduction in phagocytosis in vivo and in BV2 cells. DHA…
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