Neuroprotection, Recovery of Function and Endogenous Neurogenesis in Traumatic Spinal Cord Injury Following Transplantation of Activated Adipose Tissue.
MouseSpinal cord injuryContusionCD1Malen = n = 16 per group for the three experimental groups (LES, LS…Intraspinal transplantation at the lesion site (heterologous human lipoaspirate; 10-15 mL of lipoaspirate activated by orbital shaking at 97 x g for 10 min per preparation)Immediately after contusion
Model: Traumatic contusion spinal cord injury at T8 using an Infinite Horizon impactor, 70 kdyne applied for 1 s after laminectomy
MALS engrafted at the lesion site and significantly improved Basso Mouse Scale locomotor recovery from 24 h after transplantation, reaching 5.70 points at day 35 versus 3.6 for non-activated lipoaspirate and 2.60 for untreated lesioned mice. MALS reduced pro-inflammatory cytokine mRNA and CD68 posi…
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