THERAPY DOSSIER · th-3c1dc851222a

Mechanically-activated lipoaspirate adipose tissue (MALS)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04050111 ↗PHASE2unknown

Intra-articular autologous stromal-vascular fraction of adipose tissue for knee arthrosis

Knee Osteoarthritis

Enrolment: 30 · Results not recorded

NCT02783352 ↗NAcompleted

Microfragmented lipoaspirate tissue in arthroscopic rotator cuff repair

Rotator Cuff Tears

Enrolment: 52 · Results not recorded

NCT02855983 ↗NAcompleted

Perforating fat injections for plantar fasciosis

Plantar Fascia

Enrolment: 16 · Results not recorded

NCT03529292 ↗NAcompleted

Matrix and cells from autologous adipose tissue (AmeaCell) for facial wrinkle filling

Skin Aging

Enrolment: 23 · Results not recorded

NCT00703599 ↗PHASE1|PHASE2unknown

IV activated autologous adipose-derived stromal vascular fraction in type 1 diabetes

Type 1 Diabetes Mellitus

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30965679 ↗2019Reported benefit

Neuroprotection, Recovery of Function and Endogenous Neurogenesis in Traumatic Spinal Cord Injury Following Transplantation of Activated Adipose Tissue.

MouseSpinal cord injuryContusionCD1Malen = n = 16 per group for the three experimental groups (LES, LS…Intraspinal transplantation at the lesion site (heterologous human lipoaspirate; 10-15 mL of lipoaspirate activated by orbital shaking at 97 x g for 10 min per preparation)Immediately after contusion

Model: Traumatic contusion spinal cord injury at T8 using an Infinite Horizon impactor, 70 kdyne applied for 1 s after laminectomy

MALS engrafted at the lesion site and significantly improved Basso Mouse Scale locomotor recovery from 24 h after transplantation, reaching 5.70 points at day 35 versus 3.6 for non-activated lipoaspirate and 2.60 for untreated lesioned mice. MALS reduced pro-inflammatory cytokine mRNA and CD68 posi…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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