Effects of different corticosteroid doses and durations on smoke inhalation-induced acute lung injury and pulmonary fibrosis in the rat.
RatChemical/toxinSprague-Dawley0.4 mg/kg (low), 4 mg/kg (medium) and 40 mg/kg (high)
Model: Smoke inhalation-induced acute lung injury (SI-ALI) with late-phase pulmonary fibrosis
A medium dose of 4 mg/kg markedly improved acute-phase survival compared with 0.4 mg/kg and 40 mg/kg, attenuated lung injury, and reduced proinflammatory cytokines and alveolar neutrophil infiltration. Medium and high doses improved coagulation and fibrinolysis relative to low dose. Three-day and 7…
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