Methylprednisolone

Localized delivery of methylprednisolone sodium succinate with polymeric nanoparticles in experimental injured spinal cord model.

Model: Acute experimental spinal cord injury (trauma model)

The nanoparticle-gel delivery system produced results very similar to systemic high-dose methylprednisolone sodium succinate on inflammatory cytokine levels and ultrastructural damage, which the authors interpret as supporting localised delivery at a lower administered dose. No superiority over the…

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Surfactant protein-A nanobody-conjugated liposomes loaded with methylprednisolone increase lung-targeting specificity and therapeutic effect for acute lung injury.

Model: Acute lung injury by single intratracheal bleomycin injection at 5 mg/kg for pathology, cytokine and lavage studies or 10 mg/kg for the survival study; controls received an equal volume of intratracheal saline

Lung-targeted methylprednisolone liposomes achieved higher lung drug accumulation, peak 30.8 versus 19.2 ug/g for untargeted, better histopathological improvement and lower inflammatory cytokines, and only the 1 mg/kg targeted group showed significantly higher 10-week survival, with no detectable l…

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Methylprednisolone exacerbates acute critical illness-related corticosteroid insufficiency associated with traumatic brain injury in rats.

Model: Fluid percussion injury (traumatic brain injury)

High-dose methylprednisolone increased hypothalamic and pituitary apoptosis and exacerbated acute corticosteroid insufficiency and mortality after TBI.

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Effect of corticosteroid treatment on cell recovery by lung lavage in acute radiation-induced lung injury.

Model: Thoracic irradiation, 24 Gy

Irradiation increased total lavage cells from 3 weeks, initially neutrophils then macrophages. At 6 weeks methylprednisolone-treated irradiated rats had significantly fewer total cells, macrophages, neutrophils and lymphocytes than saline-treated irradiated rats, indicating suppression of the acute…

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Effects of methylprednisolone on collagen biosynthesis in healing acute myocardial infarction.

Model: Acute myocardial infarction

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Effects of different corticosteroid doses and durations on smoke inhalation-induced acute lung injury and pulmonary fibrosis in the rat.

Model: Smoke inhalation-induced acute lung injury (SI-ALI) with late-phase pulmonary fibrosis

A medium dose of 4 mg/kg markedly improved acute-phase survival compared with 0.4 mg/kg and 40 mg/kg, attenuated lung injury, and reduced proinflammatory cytokines and alveolar neutrophil infiltration. Medium and high doses improved coagulation and fibrinolysis relative to low dose. Three-day and 7…

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Changes of Spinal Edema and Expression of Aquaporin 4 in Methylprednisolone-treated Rats with Spinal Cord Injury.

Model: Acute spinal cord injury model

Methylprednisolone reduced spinal water content and aquaporin 4 expression relative to untreated injury, and improved histological appearance with clearer grey and white matter borders, reduced bleeding range, reduced karyopyknosis and less perivascular and neuronal oedema. The reported motor nerve…

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FNDC5 expression in Purkinje neurons of adult male rats with acute spinal cord injury following treatment with methylprednisolone.

Model: Clip compression of the spinal cord at a determined level

Spinal cord injury reduced Purkinje cell numbers and increased FNDC5 expression. Methylprednisolone inhibited apoptosis in FNDC5-immunoreactive Purkinje cells, restored these cells and reduced FNDC5 expression relative to untreated injury.

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Effects of aquaporin 4 and inward rectifier potassium channel 4.1 on medullospinal edema after methylprednisolone treatment to suppress acute spinal cord injury in rats.

Model: Acute spinal cord injury in rats; the specific injury procedure is not stated in the abstract

Methylprednisolone improved the motor function score and reduced the expression and co-expression of aquaporin 4 and Kir4.1 relative to untreated injury, which the authors interpret as inhibition of medullospinal oedema.

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Effects of methylprednisolone and 4-chloro-3-hydroxyanthranilic acid in experimental spinal cord injury in the guinea pig appear to be mediated by different and potentially complementary mechanisms.

Model: Standardised lateral compression injury of the thoracic spinal cord under anaesthesia

Methylprednisolone 150 mg/kg in split doses reduced delayed loss of motor and sensory function without significantly lowering tissue quinolinic acid. A single 60 mg/kg dose at 5 h improved sensory function but the same dose at 10 h did not. A single dose of 4-chloro-3-hydroxyanthranilic acid at 5 h…

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Two-photon-excited fluorescence microscopy as a tool to investigate the efficacy of methylprednisolone in a mouse spinal cord injury model.

Model: Compression spinal cord injury following laminectomy

Methylprednisolone improved Basso Mouse Scale recovery at 7 days, increased axonal survival at 72 hours, reduced histological damage and lowered microglial and macrophage proliferation compared with saline-treated injured mice.

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Effect of a single subacromial prednisolone injection in acute rotator cuff tears in a rat model.

Model: Surgically created full-thickness defect of the unilateral infraspinatus tendon, an acute rotator cuff tear

Subacromial methylprednisolone raised the type III to type I collagen ratio at 7 days and increased aggrecan and fibronectin at 3 days, suggesting early interference with healing, but these alterations normalised after the early inflammatory phase.

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The effect of methylprednisolone intravenous infusion on the expression of ciliary neurotrophic factor in a rat spinal cord injury model.

Model: Standardised experimental spinal cord injury

Mean ciliary neurotrophic factor expression was lower in the methylprednisolone group at 12 h (p = 0.006) and 24 h (p = 0.008) after injury than in the saline control group, with no significant difference at 6, 48 or 72 h. No functional outcome was reported.

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