Neuroprotective effects of allopurinol on spinal cord injury in rats: a biochemical and immunohistochemical study.
RatSpinal cord injuryUnspecifiedSprague-DawleyMalen = 30 male rats divided into control, trauma, and trauma plus…Intraperitoneal50 mg/kg of body weightAfter the surgical spinal cord injury procedure
Model: Spinal cord injury produced by a surgical trauma procedure
Allopurinol reduced the trauma-induced rise in myeloperoxidase and malondialdehyde, limited degenerative change in neurons and glia to mild levels, restored regular positive GFAP expression of glial processes around blood vessels, and was associated with negative Bcl-2 expression in contrast to the…
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