Drug · Xanthine dehydrogenase inhibitor (INHIBITOR; direct interaction)
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Lymphoblastic Leukemia, Acute, Childhood
Enrolment: 60 · Results not recorded
Gout
Enrolment: 248 · Results not recorded
Mania
Enrolment: 180 · Results not recorded
Renal Transplant Donor of Left Kidney · Renal Transplant Donor of Right Kidney
Enrolment: 71 · Results not recorded
Gout
Enrolment: 80 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Crotalus durissus terrificus venom-induced acute renal failure
Allopurinol reduced venom-induced lethality and hyperuricaemia whereas probenecid did not improve survival.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Spinal cord injury produced by a surgical trauma procedure
Allopurinol reduced the trauma-induced rise in myeloperoxidase and malondialdehyde, limited degenerative change in neurons and glia to mild levels, restored regular positive GFAP expression of glial processes around blood vessels, and was associated with negative Bcl-2 expression in contrast to the…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Subcutaneous implantation of polyether-polyurethane sponge discs to induce inflammatory angiogenesis and fibrovascular tissue formation
When started 24 h after implantation, allopurinol reduced angiogenesis (haemoglobin, VEGF, vessel number), inflammatory markers (MPO, NAG, TNF-alpha, CCL2) and nitric oxide and H2O2 production, while increasing collagen deposition and TGF-beta1. When started during the chronic inflammatory phase (d…
Extraction: extract · Supplied extraction confidence: 0.72. Machine-extracted fields require source verification.
Model: Whole-body caesium-137 irradiation at 0.5, 1, 2 or 4 Gy, dose rate 1.63 to 1.65 Gy per minute
Radiation caused dose-dependent, delayed inflammasome activation detectable from day 1 and sustained to day 7, returning to baseline by day 14. Allopurinol at 2 Gy significantly reduced caspase 1 activation in macrophages, dendritic cells and NK cells to sham levels and suppressed LPS-stimulated IL…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
