Vagus Nerve Stimulation Attenuates Acute Skeletal Muscle Injury Induced by Ischemia-Reperfusion in Rats.
RatIschaemia-reperfusionLimb / skeletal muscleSprague-DawleyMalen = n = 6 per group in three groups (control, I/R, I/R+VNS), 18…Direct stimulation of the isolated left cervical vagal trunk through paired Teflon-coated silver hook electrodes (0.1 mm diameter)Continuous stimulation at 20 Hz, 0.1 ms square waves, volta…Applied throughout the whole ischaemia-reperfusion process (2.5 h ischaemia plu…
Model: Skeletal muscle ischaemia-reperfusion induced by occlusion of the left femoral artery with atraumatic microvascular clamps for 2.5 h followed by 2 h reperfusion
Vagus nerve stimulation reduced muscle injury area, lowered TUNEL positive cells from 32.83% to 13.83%, reduced creatine kinase from 5060 to 1849 U/L and lactate dehydrogenase from 848 to 626 U/L, attenuated IL-1beta, IL-6 and TNF-alpha at mRNA and protein level, lowered tissue myeloperoxidase and…
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