Strategies to Understand and Optimize the Antidepressant Effects of Psilocybin (OPTIMIZE), Including taVNS
Depression
Enrolment: 141 · Results not recorded
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Device
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Depression
Enrolment: 141 · Results not recorded
Stroke · Motor Rehabilitation
Enrolment: 100 · Results not recorded
Vagus Nerve Stimulations
Enrolment: 20 · Results not recorded
Stroke
Enrolment: 30 · Results not recorded
Healthy Volunteers · Autonomic Nervous System
Enrolment: 30 · Results not recorded
Metabolic Syndrome
Enrolment: 70 · Results not recorded
Atrial Fibrillation
Enrolment: 120 · Results not recorded
Muscle Strength · Balance
Enrolment: 30 · Results not recorded
Lymphedema · Edema · Quality of Life
Enrolment: 27 · Results not recorded
Obesity
Enrolment: 5 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Chronic high-thoracic spinal cord injury
Injured rats showed increased sensitivity of heart rate and blood pressure to continuous stimulation, while clinically relevant intermittent stimulation caused only a transient fall in heart rate with no change in blood pressure. Effects lasted only during the stimulus train, no persistent hypotens…
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
Model: Skeletal muscle ischaemia-reperfusion induced by occlusion of the left femoral artery with atraumatic microvascular clamps for 2.5 h followed by 2 h reperfusion
Vagus nerve stimulation reduced muscle injury area, lowered TUNEL positive cells from 32.83% to 13.83%, reduced creatine kinase from 5060 to 1849 U/L and lactate dehydrogenase from 848 to 626 U/L, attenuated IL-1beta, IL-6 and TNF-alpha at mRNA and protein level, lowered tissue myeloperoxidase and…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.