Imbalance of Ly-6Cand Ly-6CMonocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-γ.
MouseOtherCD11b-DTR and CCR2-DTR myeloid depleter miceIntranasal
Model: Acute hyperoxia-induced neonatal lung injury (HILI), a model of bronchopulmonary dysplasia, with myeloid depletion at birth
Reduced IFN-gamma expression by interstitial monocytes and macrophages was associated with greater severity of hyperoxia-induced lung injury and increased Mmp9 mRNA. Intranasal recombinant IFN-gamma largely rescued CD11b-DTR mice from severe injury and decreased Mmp9 mRNA expression in Ly-6C high a…
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