Phase 3 Study of Interferon Gamma-1b in Idiopathic Pulmonary Fibrosis (INSPIRE)
Idiopathic Pulmonary Fibrosis · Lung Disease · Pulmonary Fibrosis
Enrolment: 826 · Results not recorded
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Biologic · Interferon gamma receptor agonist
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Idiopathic Pulmonary Fibrosis · Lung Disease · Pulmonary Fibrosis
Enrolment: 826 · Results not recorded
Breast Cancer · Colorectal Cancer · Kidney Cancer · Lung Cancer · Malignant Mesothelioma · Pancreatic Cancer
Enrolment: 40 · Results not recorded
Colorectal Cancer
Enrolment: 48 · Results not recorded
Myelodysplastic Syndromes · Myeloid Leukemia · Allogeneic Stem Cell Transplantation
Enrolment: 8 · Results not recorded
Pulmonary Tuberculosis
Enrolment: 84 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Acute hyperoxia-induced neonatal lung injury (HILI), a model of bronchopulmonary dysplasia, with myeloid depletion at birth
Reduced IFN-gamma expression by interstitial monocytes and macrophages was associated with greater severity of hyperoxia-induced lung injury and increased Mmp9 mRNA. Intranasal recombinant IFN-gamma largely rescued CD11b-DTR mice from severe injury and decreased Mmp9 mRNA expression in Ly-6C high a…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.