Human gingival mesenchymal stem cells pretreated with vesicular moringin nanostructures as a new therapeutic approach in a mouse model of spinal cord injury.
MouseSpinal cord injuryCompressionICR (CD-1)Malen = 35 mice randomised into four groups; 5 spinal cords per gro…Intravenous (tail vein)1 x 10^6 cells per animal by intravenous injection; moringi…After induction of spinal cord damage
Model: Extradural compression of the spinal cord at T6-T7 with an aneurysm clip (closing force 24 g) applied for 1 min after T5-T8 laminectomy
Moringin-pretreated GMSCs produced earlier and greater locomotor recovery than GMSCs alone, with significant BMS improvement from day 4 post-injury (day 8 for GMSCs alone) and significantly higher scores than GMSCs alone from day 9. Spinal cord morphology was restored, COX-2, IL-1beta, IL-6 and GFA…
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