THERAPY DOSSIER · th-bc9a5d6d0203

Human gingival mesenchymal stem cells pretreated for 48 h with moringin-enriched POPC liposomes (MOR-GMSCs)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03137979 ↗PHASE1/PHASE2unknown

The Safety and Efficacy Evaluation of Gingiva Mesenchymal Stem Cells Transplantation in Chronic Periodontitis Patients

Periodontitis

Enrolment: 30 · Results not recorded

NCT03570333 ↗NAcompleted

Identification and Application of Gingival Mesenchymal Stem Cells for Dental Tissue Regeneration

Gingival Recession · Lack of Keratinized Gingiva

Enrolment: 7 · Results not recorded

NCT03638154 ↗NAcompleted

Clinical Regenerative Potential of Cultured Gingival Fibroblast-Mesenchymal Stem Cells in Periodontal Intrabony Defects

Periodontal Intrabony Defect

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30942960 ↗2019Reported benefit

Human gingival mesenchymal stem cells pretreated with vesicular moringin nanostructures as a new therapeutic approach in a mouse model of spinal cord injury.

MouseSpinal cord injuryCompressionICR (CD-1)Malen = 35 mice randomised into four groups; 5 spinal cords per gro…Intravenous (tail vein)1 x 10^6 cells per animal by intravenous injection; moringi…After induction of spinal cord damage

Model: Extradural compression of the spinal cord at T6-T7 with an aneurysm clip (closing force 24 g) applied for 1 min after T5-T8 laminectomy

Moringin-pretreated GMSCs produced earlier and greater locomotor recovery than GMSCs alone, with significant BMS improvement from day 4 post-injury (day 8 for GMSCs alone) and significantly higher scores than GMSCs alone from day 9. Spinal cord morphology was restored, COX-2, IL-1beta, IL-6 and GFA…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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