Renoprotective effect of oral rehydration solution III in exertional heatstroke rats.
RatOtherSprague-DawleyMalen = 52 male rats, 13 per group in four groups; 1 rat excluded f…Oral20 mL/kg by oral administration30 min before the exercise protocol (pre-treatment)
Model: Exertional heatstroke induced by forced treadmill running at 15 m/min with 1.0 mAh electrical stimulation in a pre-warmed 37.5 degrees C environment until fatigue, with core temperature above 40.5 degrees C defining heatstroke onset, leading to acute kidney injury
Oral rehydration solution III prolonged exercise time to 132.92 plus or minus 15.89 min versus 105.77 plus or minus 7.061 min in the heatstroke group (p less than .001) and reduced serum NGAL from 52.55 (46.05 to 62.51) pg/ml to 17.04 (9.73 to 30.56) pg/ml (p = .012), with milder proximal tubular d…
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