THERAPY DOSSIER · th-b8968d7f07af

Oral rehydration solution III

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05559489 ↗Injury indicationPHASE3unknown

Enteral resuscitation bundle for moderate-sized burn, Kirtipur Hospital Nepal

Burn Body Region Unspecified · Burn Shock

Enrolment: 240 · Results not recorded

NCT07285785 ↗PHASE4recruiting

Rifaximin plus oral rehydration therapy vs ORT alone in paediatric acute diarrhoea

Diarrhea · Gastroenteritis · Bacterial Infection

Enrolment: 54 · Results not recorded

NCT01034228 ↗PHASE2completed

L-isoleucine supplemented ORS in acute childhood diarrhoea

Acute Infectious Diarrhoea in Children

Enrolment: 50 · Results not recorded

NCT01886755 ↗NAcompleted

ORS containing Lactobacillus reuteri Protectis and zinc in infants with acute gastroenteritis

Acute Gastroenteritis

Enrolment: 51 · Results not recorded

NCT03562702 ↗NAterminated

Oral rehydration (Speedlyte) vs IV rehydration in paediatric gastroenteritis

Dehydration · Acute Gastroenteritis

Enrolment: 5 · Results not recorded

NCT03105362 ↗NAterminated

Amino acid-based ORS in children with short bowel syndrome

Short Bowel Syndrome

Enrolment: 4 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30942115 ↗2019Reported benefit

Renoprotective effect of oral rehydration solution III in exertional heatstroke rats.

RatOtherSprague-DawleyMalen = 52 male rats, 13 per group in four groups; 1 rat excluded f…Oral20 mL/kg by oral administration30 min before the exercise protocol (pre-treatment)

Model: Exertional heatstroke induced by forced treadmill running at 15 m/min with 1.0 mAh electrical stimulation in a pre-warmed 37.5 degrees C environment until fatigue, with core temperature above 40.5 degrees C defining heatstroke onset, leading to acute kidney injury

Oral rehydration solution III prolonged exercise time to 132.92 plus or minus 15.89 min versus 105.77 plus or minus 7.061 min in the heatstroke group (p less than .001) and reduced serum NGAL from 52.55 (46.05 to 62.51) pg/ml to 17.04 (9.73 to 30.56) pg/ml (p = .012), with milder proximal tubular d…

Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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