Prior beta-blocker treatment decreases leukocyte responsiveness to injury.
MouseOtherC57BL/6Chronic beta-blocker infusion prior to acute injury
Model: Acute cardiac injury in mice, with parallel analysis of peripheral blood leukocytes from patients receiving beta-blocker therapy
Chronic beta-blockade increased splenic VCAM-1 and leukocyte accumulation while decreasing CCR2 expression, leukocyte migration and cardiac infiltration after acute injury; reduced CCR2 and migration were confirmed in beta-blocker-treated patients.
Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.