THERAPY DOSSIER · th-d127d136e2b7

Beta-adrenergic receptor antagonist (beta-blocker)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT07583134 ↗Injury indicationPHASE4not yet recruiting

Propranolol strategies and myocardial injury after non-cardiac surgery in breast cancer surgery

Breast Cancer · Myocardial Injury After Noncardiac Surgery

Enrolment: 100 · Results not recorded

NCT00893984 ↗PHASE4terminated

Alternative in beta blocker intolerance (ABBI) trial, nebivolol

Coronary Artery Disease

Enrolment: 6 · Results not recorded

NCT01282385 ↗PHASE4unknown

Simvastatin with non-cardioselective beta blockers in cirrhosis and portal hypertension

Liver Cirrhosis · Portal Hypertension

Enrolment: 60 · Results not recorded

NCT07054489 ↗NArecruiting

Polygenic scores to guide beta-blocker therapy in HFmrEF

Heart Failure

Enrolment: 10 · Results not recorded

NCT03730116 ↗NAcompleted

Bisoprolol/perindopril fixed-dose combination in hypertension and stable CAD (STYLE)

Arterial Hypertension · Coronary Heart Disease

Enrolment: 1909 · Results not recorded

NCT01791114 ↗NAcompleted

Brown adipose tissue activation and insulin sensitivity (cold exposure plus propranolol)

Insulin Sensitivity · Obesity

Enrolment: 39 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30920389 ↗2019Mixed findings

Prior beta-blocker treatment decreases leukocyte responsiveness to injury.

MouseOtherC57BL/6Chronic beta-blocker infusion prior to acute injury

Model: Acute cardiac injury in mice, with parallel analysis of peripheral blood leukocytes from patients receiving beta-blocker therapy

Chronic beta-blockade increased splenic VCAM-1 and leukocyte accumulation while decreasing CCR2 expression, leukocyte migration and cardiac infiltration after acute injury; reduced CCR2 and migration were confirmed in beta-blocker-treated patients.

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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