Early Intravenous Infusion of Mesenchymal Stromal Cells Exerts a Tissue Source Age-Dependent Beneficial Effect on Neurovascular Integrity and Neurobehavioral Recovery After Traumatic Cervical Spinal Cord Injury.
RatSpinal cord injuryContusionWistarFemalen = Behavioural cohorts: vehicle n = 15, BMSC n = 8, FTM HUCPVC…Intravenous, tail vein, infused manually over 5 minutes2.5 million cells in 1 ml Hank's buffer with 2 mM EDTA1 hour after spinal cord injury
Model: Moderate to severe C7-T1 clip compression/contusion spinal cord injury using a 35 g clip applied for 1 minute under isoflurane anaesthesia
All three cell types reduced acute vascular permeability, acute lesion volume and long-term glial scarring versus vehicle. FTM HUCPVC and BMSC increased vascular density, myelination and axonal density at 10 weeks. Only FTM HUCPVC produced sustained weight gain, and both term and FTM HUCPVC improve…
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