THERAPY DOSSIER · th-7f98c226a519

Term-birth human umbilical cord perivascular cells (HUCPVC), first-trimester HUCPVC and adult human bone marrow MSC

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 1

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06174597 ↗EARLY_PHASE1unknown

Umbilical cord artery-derived perivascular stem cells in critical limb ischaemia

Critical Limb Ischemia

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30912623 ↗2019Reported benefit

Early Intravenous Infusion of Mesenchymal Stromal Cells Exerts a Tissue Source Age-Dependent Beneficial Effect on Neurovascular Integrity and Neurobehavioral Recovery After Traumatic Cervical Spinal Cord Injury.

RatSpinal cord injuryContusionWistarFemalen = Behavioural cohorts: vehicle n = 15, BMSC n = 8, FTM HUCPVC…Intravenous, tail vein, infused manually over 5 minutes2.5 million cells in 1 ml Hank's buffer with 2 mM EDTA1 hour after spinal cord injury

Model: Moderate to severe C7-T1 clip compression/contusion spinal cord injury using a 35 g clip applied for 1 minute under isoflurane anaesthesia

All three cell types reduced acute vascular permeability, acute lesion volume and long-term glial scarring versus vehicle. FTM HUCPVC and BMSC increased vascular density, myelination and axonal density at 10 weeks. Only FTM HUCPVC produced sustained weight gain, and both term and FTM HUCPVC improve…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.95. Machine-extracted fields require source verification.

Loading the evidence…