Dynamic protein corona influences immune-modulating osteogenesis in magnetic nanoparticle (MNP)-infiltrated bone regeneration scaffolds in vivo.
RatFractureCalvarial/defectSprague-DawleyScaffold implantation
Model: Bone defect repair model with implantation of magnetic hydroxyapatite (MHA) scaffolds; complementary in vitro inflammatory cytokine and osteoblast cell line work
Proteins related to immune response and inflammation adsorbed onto MHA scaffolds correlated with proteins enhancing bone wound healing. MNP presence suppressed chronic inflammatory responses and promoted acute inflammatory responses, which was associated with immune cell recruitment, extracellular…
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