THERAPY DOSSIER · th-74ae0d6dd9c6

Magnetic nanoparticle (MNP)-infiltrated magnetic hydroxyapatite scaffold

Device · Magnetic-nanoparticle-infiltrated hydroxyapatite scaffold; biomaterial device.

Evidence & regulatory context

Mechanism: Magnetic-nanoparticle-infiltrated hydroxyapatite scaffold; biomaterial device.
Target: Not recorded
Injury models: Fracture
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30912535 ↗2019Reported benefit

Dynamic protein corona influences immune-modulating osteogenesis in magnetic nanoparticle (MNP)-infiltrated bone regeneration scaffolds in vivo.

RatFractureCalvarial/defectSprague-DawleyScaffold implantation

Model: Bone defect repair model with implantation of magnetic hydroxyapatite (MHA) scaffolds; complementary in vitro inflammatory cytokine and osteoblast cell line work

Proteins related to immune response and inflammation adsorbed onto MHA scaffolds correlated with proteins enhancing bone wound healing. MNP presence suppressed chronic inflammatory responses and promoted acute inflammatory responses, which was associated with immune cell recruitment, extracellular…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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