Direct Peritoneal Resuscitation Reduces Lung Injury and Caspase 8 Activity in Brain Death.
RatOtherSprague-DawleyMalen = 5 groups, n = 8 per group (40 animals)Intraperitoneal, in addition to targeted intravenous fluid30 cc of 2.5% DelflexGiven at resuscitation after acute brain death; animals assessed at 2 hours and…
Model: Acute brain death with subsequent lung injury, resuscitated with targeted intravenous fluid to maintain a mean arterial pressure of 80 mmHg
Direct peritoneal resuscitation produced 5.8-fold downregulation of TNF-alpha mRNA and a 2.7-fold decrease in TNF receptor mRNA compared with targeted intravenous fluid alone, downregulated caspase 8 mRNA, and reduced protein levels of TNF-alpha, TNF receptor, caspase 8, NF-kappaB and NF-kappaB inh…
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