THERAPY DOSSIER · th-eb52cccfc132

Direct peritoneal resuscitation with 2.5% Delflex peritoneal dialysis solution

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05195125 ↗Injury indicationPHASE1unknown

Direct Peritoneal Resuscitation in Liver Transplant Recipients at Increased Risk of Early Allograft Dysfunction

End Stage Liver Disease · Obesity · Acute Kidney Injury

Enrolment: 15 · Results not recorded

NCT01771055 ↗Injury indicationNAcompleted

Direct Peritoneal Resuscitation Effects in the Damage Control Patient

Traumatic Injury

Enrolment: 7 · Results not recorded

NCT04887480 ↗Injury indicationNAsuspended

Direct Resuscitation of the Open Peritoneum: A Randomized Controlled Trial in Non-Traumatic Patients

Wound; Abdomen · Abdomen, Acute · Wound Surgical

Enrolment: 200 · Results not recorded

NCT05208489 ↗Injury indicationNAunknown

Direct Peritoneal Resuscitation for Intra-abdominal Catastrophes

Intestinal Perforation · Intestinal Obstruction · Trauma Abdomen

Enrolment: 108 · Results not recorded

NCT01882218 ↗PHASE4withdrawn

Direct Peritoneal Resuscitation Plus Conventional Resuscitation Versus Conventional Resuscitation Alone in Hepatic Resection

Hepatic Cancer

Enrolment: 0 · Results not recorded

NCT03205553 ↗PHASE1terminated

Direct Peritoneal Resuscitation in Gastroschisis

Gastroschisis

Enrolment: 3 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30907191 ↗2019Reported benefit

Direct Peritoneal Resuscitation Reduces Lung Injury and Caspase 8 Activity in Brain Death.

RatOtherSprague-DawleyMalen = 5 groups, n = 8 per group (40 animals)Intraperitoneal, in addition to targeted intravenous fluid30 cc of 2.5% DelflexGiven at resuscitation after acute brain death; animals assessed at 2 hours and…

Model: Acute brain death with subsequent lung injury, resuscitated with targeted intravenous fluid to maintain a mean arterial pressure of 80 mmHg

Direct peritoneal resuscitation produced 5.8-fold downregulation of TNF-alpha mRNA and a 2.7-fold decrease in TNF receptor mRNA compared with targeted intravenous fluid alone, downregulated caspase 8 mRNA, and reduced protein levels of TNF-alpha, TNF receptor, caspase 8, NF-kappaB and NF-kappaB inh…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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